Open Opportunity Fund
B2B software VC backing Black and Latino founders across the US
OpenSky
Operator-led fund founded by ex-Pandemic Studios and StackCommerce founders, backing commerce-enablement tech and consumer brands at pre-seed through Series A.
Operator Collective
Venture fund and community of operators backing enterprise and B2B founders
Operator Partners
Self-funded operator collective investing own capital in technology companies from pre-seed through Series B, never leading rounds or taking board seats.
Operators Studio
Micro-VC run by solo GP Soumitra Sharma backing "Global Indian" tech founders in the US-India corridor with $50–100k pre-seed and seed checks.
Optimist Ventures
New York-based multi-stage VC backing founders in AI, InsurTech, Fintech, and industrial automation across early and late stage.
Optum Ventures
Investing in extraordinary entrepreneurs to transform healthcare
Ora Global
Spun out of Exor's century-old conglomerate in 2024, backs resilience-focused founders in AI infrastructure, security and automation.
Orange Collective
AI-native YC alumni fund backing breakout YC founders building in AI infrastructure, applied AI, agentic tools, and vertical software at seed stage.
OrbiMed
Global leader investing in healthcare from early-stage to public companies
Oregon Venture Fund
Regional VC providing capital and support to Oregon/SW Washington startups and growth companies
Origin Ventures
Early-stage VC leading seed and Series A rounds for 25+ years, now focused on AI infrastructure, AI-native software, and frontier tech.
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Early-stage fund that skips board seats to stay founder-aligned, backing technically deep, relentless founders in vertical software and fintech.
Orlando Health Ventures
Corporate venture arm of Orlando Health backing medtech, biotech, and health-services startups that pilot within the health system before scaling.
Osage Venture Partners
Investing in early-stage B2B software start-ups for over two decades
OSF Ventures
Corporate arm of OSF HealthCare's hospital system, investing post-seed in health IT and medtech startups that partner directly with its clinicians.
Outlander VC
Early-stage VC that funds exceptional founders and their outlandish visions first, often investing pre-product and pre-revenue.
Outset Capital
Pre-seed and seed fund investing in AI, deep tech, and future of work
Outsiders Fund
Early-stage VC backing European founders building enduring tech companies
Overlap Holdings
Frontier tech VC investing in Seed through Series B, pairing equity with free debt advisory and non-dilutive government funding support.
Overmatch Ventures
Early-stage VC backing deep tech, defense, and space founders in the US. Built by military veterans and operators investing from Seed through Series B.
Overture
Early-stage VC investing in energy, AI, resilience, and industrial transformation startups, helping founders win government support.
Overwater Ventures
Early-stage fund led by ex-a16z partner Kristina Simmons, backing pre-seed/seed breakthrough tech that improves human and planetary health.
OVNI Capital
Paris- and San Francisco-based pre-seed and seed VC backing European deep tech founders building in hardware, biotech, quantum, cybersecurity, and AI.
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