Ubiquity Ventures
Seed-stage VC focused on software beyond the screen startups
UCB Ventures
UCB's evergreen corporate VC (2017) backs early-stage cell/gene therapy, RNA modulation and regenerative medicine startups beyond its core focus.
UCI Health Ventures
Corporate VC arm of UCI Health investing in early-stage healthcare innovators
Umami Capital
Concentrated early-stage fund focused on high-conviction technology investments
Unbundled Capital
Permanent capital firm of operators investing in one or two founder-led vertical software companies per year past product-market fit.
UNC Health Ventures
Corporate VC arm of UNC Health System, giving health-tech portfolio companies direct access to its hospital network for clinical validation.
Uncommon Denominator
Early-stage VC backing consumer brands, B2B SaaS, and frontier tech companies with a distinctive skill-spike in one core area.
Uncork Capital
Early-stage venture firm partnering with founders from day one
Uncorrelated
Solo GP fund investing in early-stage infrastructure software — both traditional and decentralized — with $750M AUM across three funds and 100+ portfolio companies.
Underdog Labs
Pre-seed fund run by serial entrepreneurs backing belief-driven founders pre-product and pre-monetization, primarily in B2B software and consumer. Checks typically $1M or less.
Underscore VC
Boston-based pre-seed and seed investor in B2B software, operating an open-source profit-sharing model with a community of 1,800+ operators.
Undeterred Capital
US deep-tech VC backing scientific-breakthrough founders in biological platforms and applied robotics, investing mostly at pre-seed.
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Investing at the edge of large markets under transformation
United Airlines Ventures
Corporate VC investing in aviation, energy, and travel innovation
Unless
Investment firm backing visionary companies transforming industrial systems through manufacturing, automation, and climate adaptation.
Unpopular Ventures
Rolling fund and syndicate on AngelList backing non-consensus early-stage founders globally across any sector.
Unshackled Ventures
The only pre-seed VC exclusively backing immigrant founders in the US, providing capital, visa sponsorship, and immigration support from Day 0 — pre-product, pre-revenue, pre-visa.
Unusual Ventures
A seed-stage venture capital firm focused on providing hands-on operational support to help early-stage technical founders achieve product-market fit.
UP.Partners
Early-stage fund investing in hardware-software companies across ground, air, sea, and space, focused on transforming how people and goods move.
Upfront Ventures
Early-stage venture firm backing founders building transformational companies
UpHonest Capital
Sector-agnostic early-stage VC in Silicon Valley investing in Seed through Series A, with over 400 portfolio companies including Checkr and Rippling.
UPMC Enterprises
Corporate VC and innovation arm of UPMC, a $28B health system, investing from early to growth stage in digital health, translational sciences, diagnostics, and therapeutics.
UpscaleX
AI-native seed fund and accelerator co-building agentic commerce startups alongside technically strong founders across the AI stack.
UpWest
Pre-seed and seed fund backing Israeli founders entering the US market across cybersecurity, enterprise SaaS, DevOps, digital healthcare, and fintech, with 90+ portfolio companies.
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